Mutagenic Principle(s) in Tryptophan and Phenylalanine Pyrolysis Products
نویسندگان
چکیده
منابع مشابه
Metabolic activation of mutagenic tryptophan pyrolysis products by rat liver microsomes.
In an attempt to determine whether cytochrome P-450 metabolizes tryptophan pyrolysis products, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) and 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) to active forms, studies were done using microsomes and the 9000 x g supernatant (S-9) from polychlorinated biphenyl mixture-treated rat livers together with Salmonella typhimurium TA 98 as a te...
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Metabolic activation of a tryptophan pyrolysate, 3-amino-1 methyl-5H-pyrido[4,3-D ]indole (Trp-P-2), in liver microsomes from rats, mice, hamsters, guinea pigs, and rabbits was studied to know whether AMiydroxylation is a common obligatory step for mutagenic activation of Trp-P-2. Among hepatic microsomes obtained from untreated animals, the highest activity of Trp-P-2 W-hydroxylase was observe...
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Metabolic activation of a tryptophan pyrolysate, 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2), in liver microsomes from rats, mice, hamsters, guinea pigs, and rabbits was studied to know whether N-hydroxylation is a common obligatory step for mutagenic activation of Trp-P-2. Among hepatic microsomes obtained from untreated animals, the highest activity of Trp-P-2 N-hydroxylase was observed...
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The medicinal plant bitter apple belongs to Cucurbitaceae family. To study the effect of phenylalanine and tryptophan amino acids on morphological and physiological characteristics of Citrullus colocynthis L., an investigation was conducted according to a completely randomized block design with four treatments and three replications in University of Zanjan, Iran. The studied factors were consis...
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Four different types of coal have been pyrolyzed in a laminar flow, drop tube furnace in order to establish a relationship between polycyclic aromatic compound (PAC) evolution and mutagenicity. Temperatures of 900K to 1700K and particle residence times up to 0.3 sec were chosen to best simulate conditions of rapid rate pyrolysis in pulverized (44-53 microns) coal combustion. The specific mutage...
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ژورنال
عنوان ژورنال: Proceedings of the Japan Academy
سال: 1977
ISSN: 0021-4280
DOI: 10.2183/pjab1945.53.58